CLS Clinical Chemistry 3

Question 1

Which method is used to measure serum protein electrophoresis and can identify monoclonal gammopathy (M-spike)?

Accepted Answer

Agarose gel or capillary zone electrophoresis

Answer

Biuret colorimetric assay

Answer

Bradford protein assay

Answer

Immunoturbidimetry

Question 2

A patient's urine osmolality is 900 mOsm/kg while serum osmolality is 285 mOsm/kg. Which statement best describes this result?

Accepted Answer

The kidneys are appropriately concentrating urine

Answer

The kidneys have lost concentrating ability

Answer

The patient has diabetes insipidus

Answer

The patient has syndrome of inappropriate ADH (SIADH)

Question 3

Which enzyme marker is elevated in hepatic disease, bone disease, and pregnancy, but is NOT specific to any one tissue?

Accepted Answer

Alkaline phosphatase (ALP)

Answer

Gamma-glutamyl transferase (GGT)

Answer

Alanine aminotransferase (ALT)

Answer

Creatine kinase (CK)

Question 4

In iron deficiency anemia, which laboratory pattern would you expect?

Accepted Answer

Low serum iron, high TIBC, low ferritin, low transferrin saturation

Answer

Low serum iron, low TIBC, high ferritin, high transferrin saturation

Answer

High serum iron, low TIBC, high ferritin, high transferrin saturation

Answer

Normal serum iron, normal TIBC, low ferritin, normal transferrin saturation

Question 5

Which assay is used to measure the functional activity of the coagulation cascade and would be prolonged in a patient on warfarin therapy?

Accepted Answer

Prothrombin time (PT) / INR

Answer

Activated partial thromboplastin time (aPTT)

Answer

Thrombin time (TT)

Answer

Bleeding time

Question 6

A serum calcium of 12.5 mg/dL with an elevated PTH level most likely indicates which condition?

Accepted Answer

Primary hyperparathyroidism

Answer

Malignancy-associated hypercalcemia

Answer

Vitamin D toxicity

Answer

Milk-alkali syndrome

Question 7

Which interference can cause falsely low hemoglobin measurements when using the cyanmethemoglobin spectrophotometric method?

Accepted Answer

Hyperlipidemia causing turbidity in the sample

Answer

Hemolysis releasing intracellular hemoglobin

Answer

Elevated bilirubin causing spectral interference

Answer

Methemoglobin formation in the cuvette