ABO Ocular Oncology

Question 1

What is the most common primary intraocular malignancy in adults?

Accepted Answer

Uveal melanoma

Answer

Retinoblastoma

Answer

Primary intraocular lymphoma

Answer

Metastatic carcinoma

Question 2

Which genetic mutation is most commonly associated with uveal melanoma?

Accepted Answer

GNAQ/GNA11

Answer

BRAF V600E

Answer

KRAS

Answer

RB1

Question 3

What is the most common site of distant metastasis from uveal melanoma?

Accepted Answer

Liver

Answer

Lung

Answer

Brain

Answer

Bone

Question 4

Retinoblastoma results from biallelic inactivation of which tumor suppressor gene?

Accepted Answer

RB1

Answer

TP53

Answer

BRCA1

Answer

NF1

Question 5

Which of the following is the most common benign intraocular tumor in adults?

Accepted Answer

Choroidal nevus

Answer

Choroidal hemangioma

Answer

Iris cyst

Answer

Melanocytoma

Question 6

The Collaborative Ocular Melanoma Study (COMS) demonstrated equivalence between enucleation and which treatment for medium-sized choroidal melanoma?

Accepted Answer

I-125 episcleral plaque brachytherapy

Answer

External beam radiation

Answer

Proton beam radiation

Answer

Transpupillary thermotherapy

Question 7

Which B-scan ultrasonography finding is most characteristic of choroidal melanoma?

Accepted Answer

Low-to-medium internal reflectivity with acoustic hollowing and choroidal excavation

Answer

High internal reflectivity

Answer

Dense calcification

Answer

Cystic spaces with septations