PTCB Pharmacology #5 3

Question 1

Which drug is the antidote for heparin overdose?

Accepted Answer

Protamine sulfate

Answer

Vitamin K

Answer

Fresh frozen plasma

Answer

Phytonadione

Question 2

Which class of drug do "-zosin" suffix drugs (e.g., tamsulosin, doxazosin) belong to?

Accepted Answer

Alpha-1 adrenergic blockers

Answer

Beta-blockers

Answer

ACE inhibitors

Answer

Calcium channel blockers

Question 3

Varenicline (Chantix) is used for smoking cessation because it:

Accepted Answer

Partially activates nicotinic acetylcholine receptors while blocking nicotine binding

Answer

Is a nicotine replacement providing low-dose nicotine

Answer

Blocks dopamine receptors to reduce reward from smoking

Answer

Increases nicotine metabolism to reduce cravings

Question 4

Drug-induced lupus (DIL) is most commonly associated with which drug?

Accepted Answer

Hydralazine

Answer

Aspirin

Answer

Metoprolol

Answer

Omeprazole

Question 5

Which of the following is the primary reason why grapefruit juice interacts with simvastatin?

Accepted Answer

It inhibits intestinal CYP3A4, increasing simvastatin bioavailability and myopathy risk

Answer

It inhibits renal excretion of simvastatin

Answer

It induces CYP2D6 metabolism

Answer

It decreases gastric pH, increasing absorption

Question 6

What is the mechanism of action of memantine (Namenda), used in Alzheimer's disease?

Accepted Answer

NMDA receptor antagonism

Answer

Acetylcholinesterase inhibition

Answer

Beta-amyloid plaque reduction

Answer

Dopamine agonism