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Pharmaceutical Sciences Flashcards

6 cards from real PSI practice questions. Tap to flip, then mark Knew It or Still Learning — missed cards come back until you master them.

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  1. The British Pharmacopoeia (BP) is a legally recognised standard for medicinal product quality in:

    Answer: The United Kingdom and Ireland

    The BP is the official pharmacopoeia for the UK and Republic of Ireland. Medicinal products must comply with BP standards unless otherwise stated in a marketing authorisation.

  2. Which method of sterilisation uses moist heat under pressure?

    Answer: Autoclaving

    Autoclaving (121°C, 15 psi, 15 minutes) uses saturated steam under pressure to kill microorganisms including spores. It is the preferred method for aqueous injections and surgical instruments.

  3. Adsorption onto packaging components is a stability concern particularly for which type of drug?

    Answer: Protein biologics and low-dose drugs

    Proteins and peptides, and drugs present in very small amounts, can adsorb onto glass or plastic container surfaces, reducing the available dose and causing potency loss.

  4. Which route of administration completely avoids hepatic first-pass effect?

    Answer: Sublingual

    Sublingual absorption directly enters systemic venous circulation via the oral mucosa, completely bypassing the portal circulation and hepatic first-pass metabolism.

  5. Fickian diffusion through a membrane is enhanced by:

    Answer: Increased concentration gradient and membrane surface area

    Fick's first law states: flux = D × A × ΔC / h. Flux increases with diffusion coefficient (D), surface area (A), and concentration gradient (ΔC), but decreases with membrane thickness (h).

  6. Which international quality standard covers pharmaceutical Good Manufacturing Practice in the EU?

    Answer: EU GMP Guidelines (EudraLex Volume 4)

    EU GMP is published in EudraLex Volume 4 and sets legally binding standards for manufacture of medicinal products in the EU/EEA, including Ireland.