PSA Drug Interactions

Question 1

What is a drug-drug interaction?

Accepted Answer

When one drug affects the activity of another when both are administered together

Answer

When a drug interacts with food

Answer

When a drug causes an allergic reaction

Answer

When a drug expires

Question 2

What enzyme system is most commonly involved in drug metabolism interactions?

Accepted Answer

Cytochrome P450 (CYP450) enzyme system

Answer

Digestive enzymes

Answer

Respiratory enzymes

Answer

Cardiac enzymes

Question 3

What happens when a CYP450 inhibitor is given with a substrate drug?

Accepted Answer

The substrate drug level increases because its metabolism is slowed

Answer

The substrate drug level decreases

Answer

No effect occurs

Answer

The inhibitor stops working

Question 4

Why is warfarin particularly prone to drug interactions?

Accepted Answer

It has a narrow therapeutic index, is highly protein-bound, and is metabolized by multiple CYP enzymes

Answer

It is always given in high doses

Answer

It is not absorbed orally

Answer

It has no known interactions

Question 5

What is the interaction between ACE inhibitors and potassium-sparing diuretics?

Accepted Answer

Both increase potassium levels, risking dangerous hyperkalemia

Answer

They cancel each other out

Answer

They decrease potassium levels

Answer

No interaction exists

Question 6

What is serotonin syndrome?

Accepted Answer

A potentially life-threatening condition caused by excessive serotonin, often from combining serotonergic drugs

Answer

A mild headache from antidepressants

Answer

A withdrawal symptom

Answer

An allergic reaction