Pharmacy Pharmacokinetics 2

Question 1

Which plasma protein is the primary binding protein for most acidic drugs?

Accepted Answer

Albumin

Answer

Alpha-1-acid glycoprotein (AAG)

Answer

Globulin

Answer

Fibrinogen

Question 2

A patient with severe hypoalbuminemia is receiving a drug that is 95% protein-bound. What effect would you expect?

Accepted Answer

Increased free drug concentration and potential toxicity

Answer

Decreased free drug concentration and reduced effect

Answer

No change because total drug concentration is unchanged

Answer

Increased renal clearance of the drug

Question 3

Which of the following best describes zero-order pharmacokinetics?

Accepted Answer

Drug concentration decreases by a fixed amount per unit time and half-life increases with dose

Answer

Drug concentration decreases by a fixed percentage per unit time

Answer

Drug half-life remains constant regardless of dose

Answer

Drug is rapidly eliminated and follows linear kinetics

Question 4

Creatinine clearance (CrCl) is most commonly used clinically to estimate:

Accepted Answer

Renal function for drug dosing adjustments

Answer

Hepatic metabolic capacity

Answer

Drug protein binding in plasma

Answer

Volume of distribution of renally cleared drugs

Question 5

The Cockcroft-Gault equation is used in pharmacy practice to estimate:

Accepted Answer

Creatinine clearance (CrCl) as a surrogate for GFR

Answer

Hepatic clearance based on Child-Pugh score

Answer

Volume of distribution for obese patients

Answer

Drug half-life in pediatric populations

Question 6

A drug follows first-order kinetics with a half-life of 6 hours. After 18 hours, approximately what percentage of the original dose remains?

Accepted Answer

12.5%

Answer

50%

Answer

25%

Answer

6.25%

Question 7

Steady-state plasma concentration during continuous dosing is typically reached after approximately:

Accepted Answer

3–5 half-lives

Answer

1 half-life

Answer

10 half-lives

Answer

The number depends only on dose size, not half-life