Pharmacy Sterile Compounding Flashcards
6 cards from real Pharmacy practice questions. Tap to flip, then mark Knew It or Still Learning — missed cards come back until you master them.
Read the first 6 Pharmacy Sterile Compounding flashcards as text
What is the correct procedure for performing a media-fill test in sterile compounding?
Answer: Simulate the actual compounding process using a microbial growth medium instead of the drug
A media-fill test replicates the compounding process using soybean–casein digest (tryptic soy broth) media to assess whether a compounder's technique can introduce microbial contamination.
A pharmacy technician accidentally touches the tip of a syringe needle during sterile compounding. What is the correct action?
Answer: Discard the needle, obtain a new one, and resume with proper technique
Any contact with a critical site such as a needle tip compromises sterility; the contaminated needle must be discarded and replaced before compounding continues.
What is the significance of beyond-use dating (BUD) versus expiration dating for CSPs?
Answer: BUD is assigned based on preparation conditions and storage, while expiration dates are set by manufacturers
Expiration dates are determined by manufacturers through stability studies; BUDs are assigned by the compounder based on USP standards, preparation conditions, and stability data.
Which cleanroom classification is required for an anteroom (ante-area) adjacent to an ISO Class 7 buffer room?
Answer: ISO Class 8
USP requires that the ante-area adjacent to an ISO Class 7 buffer room maintain at least ISO Class 8 air quality to create an air pressure gradient that minimizes contamination.
When compounding a total parenteral nutrition (TPN) solution, in what order should ingredients typically be added to minimize incompatibilities?
Answer: Amino acids and dextrose first, then lipids last if a 3-in-1 admixture
In TPN compounding, amino acids and dextrose are typically combined first to dilute electrolytes before adding lipids last in a 3-in-1 (total nutrient admixture) preparation to maintain emulsion stability.
What is the primary reason that calcium and phosphate concentrations must be carefully monitored in TPN solutions?
Answer: They can form an insoluble precipitate that may cause pulmonary emboli if infused
Calcium phosphate precipitation in TPN solutions is a well-documented life-threatening hazard; the insoluble particles can occlude pulmonary capillaries if the TPN is administered intravenously.