Pharmacy Pharmacy Sterile Compounding 3

Question 1

What is the correct procedure for performing a media-fill test in sterile compounding?

Accepted Answer

Simulate the actual compounding process using a microbial growth medium instead of the drug

Answer

Fill empty vials with sterile water and incubate them

Answer

Test a finished CSP by injecting it into growth media

Answer

Swab the LAFW surface and plate onto agar

Question 2

A pharmacy technician accidentally touches the tip of a syringe needle during sterile compounding. What is the correct action?

Accepted Answer

Discard the needle, obtain a new one, and resume with proper technique

Answer

Wipe the needle tip with 70% IPA and continue

Answer

Cap the needle immediately and inform the pharmacist after compounding

Answer

Complete the preparation and label it for additional sterility testing

Question 3

What is the significance of beyond-use dating (BUD) versus expiration dating for CSPs?

Accepted Answer

BUD is assigned based on preparation conditions and storage, while expiration dates are set by manufacturers

Answer

BUD and expiration date are interchangeable terms

Answer

Expiration dates apply to compounded products while BUD applies only to manufactured drugs

Answer

BUD is always longer than the manufacturer's expiration date

Question 4

Which cleanroom classification is required for an anteroom (ante-area) adjacent to an ISO Class 7 buffer room?

Accepted Answer

ISO Class 8

Answer

ISO Class 5

Answer

ISO Class 7

Answer

ISO Class 6

Question 5

When compounding a total parenteral nutrition (TPN) solution, in what order should ingredients typically be added to minimize incompatibilities?

Accepted Answer

Amino acids and dextrose first, then lipids last if a 3-in-1 admixture

Answer

Lipids first, then electrolytes, then amino acids

Answer

Electrolytes first, then dextrose, then amino acids

Answer

All components simultaneously through separate ports

Question 6

What is the primary reason that calcium and phosphate concentrations must be carefully monitored in TPN solutions?

Accepted Answer

They can form an insoluble precipitate that may cause pulmonary emboli if infused

Answer

They lower the pH below the stability range for amino acids

Answer

Excess calcium chelates the preservative in the bag

Answer

High phosphate destroys vitamin additives in the TPN