Pharm.D. Doctor of Pharmacy Pharmacokinetics and Pharmacodynamics

Question 1

Which pharmacokinetic parameter describes the volume of plasma cleared of a drug per unit time?

Accepted Answer

Clearance

Answer

Volume of distribution

Answer

Half-life

Answer

Bioavailability

Question 2

A drug has a half-life of 6 hours. Approximately how long does it take to reach steady-state concentration?

Accepted Answer

24–30 hours

Answer

6 hours

Answer

12 hours

Answer

48 hours

Question 3

Which of the following best defines the volume of distribution (Vd)?

Accepted Answer

A proportionality constant relating plasma concentration to total drug in the body

Answer

The rate at which drug is eliminated

Answer

The fraction of drug absorbed systemically

Answer

The time to reach maximum plasma concentration

Question 4

What is the effect of first-pass metabolism on oral bioavailability?

Accepted Answer

Decreases bioavailability

Answer

Increases bioavailability

Answer

Has no effect on bioavailability

Answer

Only affects IV bioavailability

Question 5

Which pharmacodynamic concept describes the relationship between drug concentration and the maximum possible effect?

Accepted Answer

Emax model

Answer

EC50

Answer

Therapeutic index

Answer

Zero-order kinetics

Question 6

A drug following zero-order kinetics is eliminated at:

Accepted Answer

A constant amount per unit time

Answer

A rate proportional to its concentration

Answer

A rate proportional to the square of its concentration

Answer

A rate that doubles with each dose