Pharm.D. Doctor of Pharmacy Pharmaceutical Chemistry and Drug Design

Question 1

Which functional group is primarily responsible for the acidic properties of aspirin?

Accepted Answer

Carboxylic acid group

Answer

Ester group

Answer

Hydroxyl group

Answer

Ketone group

Question 2

In prodrug design, the active drug is released after:

Accepted Answer

Metabolic or chemical conversion in the body

Answer

Binding to its receptor target

Answer

Renal filtration

Answer

Passive diffusion across the blood-brain barrier

Question 3

Which stereochemical concept explains why (R)- and (S)-ibuprofen differ in pharmacological activity?

Accepted Answer

Chirality and enantioselectivity

Answer

Constitutional isomerism

Answer

Geometric isomerism

Answer

Conformational isomerism

Question 4

What does structure-activity relationship (SAR) studies primarily determine?

Accepted Answer

How chemical structure modifications affect pharmacological activity

Answer

How quickly a drug is absorbed

Answer

The molecular weight of candidate drugs

Answer

The route of administration for new drugs

Question 5

Which principle in drug design states that increasing lipophilicity generally improves CNS penetration?

Accepted Answer

Lipinski's Rule of Five

Answer

Henderson-Hasselbalch principle

Answer

Biopharmaceutics Classification System

Answer

Lock-and-key model

Question 6

Beta-lactam antibiotics exert their antibacterial effect by:

Accepted Answer

Irreversibly binding to penicillin-binding proteins (PBPs) and inhibiting cell wall synthesis

Answer

Inhibiting DNA gyrase

Answer

Disrupting the bacterial cell membrane

Answer

Inhibiting the 30S ribosomal subunit