Practice Test GeeksMFDS Part 1 Practice Test
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Human Disease Flashcards

6 cards from real MFDS practice questions. Tap to flip, then mark Knew It or Still Learning — missed cards come back until you master them.

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  1. Which cardiac condition most significantly increases the risk of prolonged QT syndrome with erythromycin?

    Answer: Pre-existing QT prolongation or concurrent QT-prolonging drugs

    Erythromycin prolongs the cardiac QT interval by blocking hERG potassium channels; this risk is greatly amplified in patients with a pre-existing long QT interval or on other QT-prolonging drugs.

  2. Behçet's disease is characterised by the triad of:

    Answer: Oral ulcers, genital ulcers and uveitis

    Behçet's disease is a systemic vasculitis characterised by the classic triad of recurrent oral ulcers, genital ulcers and uveitis (International Study Group criteria).

  3. Which liver disease most significantly impairs drug metabolism in dental practice?

    Answer: Severe cirrhosis

    Severe cirrhosis markedly reduces hepatic drug-metabolising capacity (cytochrome P450 activity) and can impair clotting factor synthesis, both clinically relevant in dental prescribing.

  4. A patient with chronic renal failure presents for extraction. The main concern regarding drug prescribing is:

    Answer: Accumulation of renally excreted drugs and metabolites

    In chronic renal failure, renally excreted drugs (e.g. some penicillins, NSAIDs) accumulate to toxic levels, requiring dose reduction or alternative agents.

  5. Which immune deficiency syndrome most significantly predisposes to invasive oral candidiasis?

    Answer: HIV/AIDS (CD4 <200)

    Severe CD4 lymphocytopenia in HIV/AIDS (particularly CD4 <200 cells/μL) profoundly impairs cell-mediated immunity, predisposing to invasive and oropharyngeal candidiasis.

  6. Which feature distinguishes Crohn's disease from ulcerative colitis in oral manifestations?

    Answer: Cobblestone buccal mucosa and lip swelling occur in Crohn's

    Oral Crohn's disease produces characteristic cobblestone (polypoid) buccal mucosa, lip swelling (orofacial granulomatosis) and linear ulcers not seen in UC.