Mesothelioma Therapy Immunotherapy and Targeted Therapy 2

Question 1

Mesothelin is a target in mesothelioma because it is:

Accepted Answer

Overexpressed on mesothelioma cell surfaces

Answer

Absent on mesothelioma cells

Answer

A mutation driver

Answer

Present only in blood

Question 2

Amatuximab is an experimental targeted therapy for mesothelioma that targets which protein?

Accepted Answer

Mesothelin

Answer

EGFR

Answer

VEGFR

Answer

PD-L1

Question 3

CAR-T cell therapy in mesothelioma research primarily targets which antigen?

Accepted Answer

Mesothelin

Answer

HER2

Answer

CD19

Answer

EGFR

Question 4

Pembrolizumab targets which checkpoint molecule?

Accepted Answer

PD-1

Answer

CTLA-4

Answer

PD-L1

Answer

LAG-3

Question 5

Avelumab differs from nivolumab and pembrolizumab in that it targets:

Accepted Answer

PD-L1 on tumor cells

Answer

PD-1 on T cells

Answer

CTLA-4 on T cells

Answer

VEGF in circulation

Question 6

Which targeted mutation makes some mesothelioma patients potentially eligible for PARP inhibitor therapy?

Accepted Answer

BAP1 mutation (loss of function)

Answer

KRAS mutation

Answer

EGFR mutation

Answer

ALK rearrangement