Mesothelioma Diagnosis Staging and Prognosis 2

Question 1

N2 disease in the IMIG TNM system for mesothelioma refers to involvement of which lymph nodes?

Accepted Answer

Subcarinal or contralateral mediastinal nodes

Answer

Ipsilateral bronchopulmonary nodes

Answer

Axillary nodes

Answer

Cervical nodes

Question 2

Which prognostic scoring system for mesothelioma uses lactate dehydrogenase, age, performance status, and hemoglobin?

Accepted Answer

CALGB prognostic score

Answer

EORTC score

Answer

IMIG TNM

Answer

Brigham staging

Question 3

What does T4 disease represent in the IMIG staging of pleural mesothelioma?

Accepted Answer

Direct extension into contralateral pleura, spine, or heart

Answer

Invasion of the diaphragm only

Answer

Involvement of the pericardium without cardiac invasion

Answer

Ipsilateral pleural disease with effusion

Question 4

Which performance status scale is most commonly used to assess mesothelioma patients' fitness for treatment?

Accepted Answer

ECOG performance status

Answer

Karnofsky score only

Answer

WHO disability grade

Answer

NYHA functional class

Question 5

Peritoneal mesothelioma staging uses the Peritoneal Cancer Index (PCI), where a PCI score above what threshold generally predicts incomplete cytoreduction?

Accepted Answer

20

Answer

5

Answer

50

Answer

10

Question 6

Which first-line chemotherapy regimen is FDA-approved and standard of care for unresectable pleural mesothelioma?

Accepted Answer

Cisplatin plus pemetrexed

Answer

Carboplatin plus paclitaxel

Answer

Gemcitabine plus oxaliplatin

Answer

FOLFOX