Mesothelioma Diagnosis Biopsy and Pathology 2

Question 1

Which stain is used on routine pathology sections to first evaluate suspected mesothelioma?

Accepted Answer

Hematoxylin and eosin (H&E)

Answer

PAS stain

Answer

Masson trichrome

Answer

Sudan black

Question 2

Which IHC marker is typically negative in mesothelioma but positive in metastatic breast carcinoma to the pleura?

Accepted Answer

GATA3

Answer

Calretinin

Answer

WT1

Answer

D2-40

Question 3

D2-40 (podoplanin) IHC staining in mesothelioma primarily highlights which feature?

Accepted Answer

Lymphatic differentiation and mesothelial cells

Answer

Vascular endothelium

Answer

Necrosis zones

Answer

Mitotic figures

Question 4

FISH (fluorescence in situ hybridization) for CDKN2A (p16) deletion is used in mesothelioma pathology to:

Accepted Answer

Distinguish malignant mesothelioma from benign mesothelial hyperplasia

Answer

Determine asbestos fiber type

Answer

Assess treatment response

Answer

Grade tumor differentiation

Question 5

In sarcomatoid mesothelioma, which IHC marker is most reliably positive?

Accepted Answer

Pancytokeratin

Answer

Calretinin

Answer

WT1

Answer

D2-40

Question 6

What is the significance of the NF2 gene mutation in mesothelioma pathology?

Accepted Answer

It is one of the most common somatic mutations found in mesothelioma

Answer

It predicts response to immunotherapy

Answer

It indicates asbestos-free etiology

Answer

It is found only in pericardial mesothelioma