Medical Technologist Test Immunology and Serology

Question 1

Which immunoglobulin class is the FIRST to be produced during a primary immune response?

Accepted Answer

IgM

Answer

IgG

Answer

IgA

Answer

IgE

Question 2

The complement pathway activated directly by antigen-antibody complexes is the:

Accepted Answer

Classical pathway

Answer

Lectin pathway

Answer

Alternative pathway

Answer

Mannose-binding pathway

Question 3

Type I hypersensitivity (anaphylactic) reactions are primarily mediated by which immunoglobulin?

Accepted Answer

IgE

Answer

IgG

Answer

IgM

Answer

IgA

Question 4

A homogeneous ANA fluorescence pattern is most commonly associated with antibodies against:

Accepted Answer

Anti-dsDNA or anti-histone antibodies

Answer

Anti-Sm antibodies

Answer

Anti-SSA/Ro antibodies

Answer

Anti-centromere antibodies

Question 5

In the zone of equivalence during a precipitation reaction, which of the following occurs?

Accepted Answer

Optimal lattice formation produces maximum precipitate

Answer

Antigen is in excess, inhibiting precipitate

Answer

Antibody is in excess, inhibiting precipitate

Answer

No precipitation occurs due to soluble complexes

Question 6

Rheumatoid factor (RF) is an autoantibody directed against which target?

Accepted Answer

The Fc portion of IgG

Answer

Double-stranded DNA

Answer

Histone proteins

Answer

Cyclic citrullinated peptides (CCP)

Question 7

Which technique uses fluorescent-labeled antibodies to detect antigens in tissue sections or cells?

Accepted Answer

Direct immunofluorescence

Answer

Ouchterlony double diffusion

Answer

Latex agglutination

Answer

Rocket electrophoresis