Clinical Procedures and Protocols Flashcards
7 cards from real KAPS practice questions. Tap to flip, then mark Knew It or Still Learning — missed cards come back until you master them.
Read the first 7 Clinical Procedures and Protocols flashcards as text
According to ASHP guidelines, which is the correct method for filtering out particles when drawing up amphotericin B deoxycholate?
Answer: Use a 5-micron filter
A 1-micron in-line filter may be used with amphotericin B deoxycholate; a 0.22-micron filter would remove the colloidal drug particles.
A pharmacist is reviewing a patient's medication profile and notes that the patient is taking both St. John's Wort and cyclosporine. What is the expected clinical outcome?
Answer: Decreased cyclosporine levels and transplant rejection risk
St. John's Wort is a potent CYP3A4 and P-glycoprotein inducer that significantly reduces cyclosporine blood levels, risking organ rejection.
When performing a final verification check on a compounded sterile preparation, which action is part of the physical inspection step?
Answer: Checking for particulate matter, color, and clarity
Physical inspection includes examining the preparation for visible particulates, appropriate color, and clarity against a light and dark background.
A patient with severe hepatic impairment (Child-Pugh Class C) is prescribed a medication primarily eliminated via hepatic metabolism. The anticipated pharmacokinetic change is:
Answer: Increased half-life and decreased clearance
Severe hepatic impairment reduces hepatic blood flow and enzyme activity, decreasing clearance and prolonging the drug's half-life.
Which clinical protocol should be followed when administering methotrexate high-dose therapy to prevent nephrotoxicity?
Answer: Alkalinize the urine with sodium bicarbonate
Urinary alkalinization with sodium bicarbonate increases methotrexate solubility in urine, preventing precipitation and nephrotoxicity.
During a clinical pharmacist's patient interview, a patient states they take their antihypertensive 'when they feel their blood pressure is high.' This represents which type of adherence barrier?
Answer: Intentional non-adherence based on health beliefs
Symptom-driven medication taking reflects intentional non-adherence rooted in the patient's health belief that medication is only needed when symptoms are perceived.
What is the primary purpose of leucovorin rescue following high-dose methotrexate therapy?
Answer: To bypass dihydrofolate reductase and restore folate function in normal cells
Leucovorin is a reduced folate that bypasses the DHFR block caused by methotrexate, rescuing normal cells without reversing antitumor effects.