Clinical Procedures and Protocols Flashcards
7 cards from real KAPS practice questions. Tap to flip, then mark Knew It or Still Learning — missed cards come back until you master them.
Read the first 7 Clinical Procedures and Protocols flashcards as text
A pharmacist is reviewing a medication order for vancomycin. Which pharmacokinetic parameter is most important to monitor for efficacy in serious infections?
Answer: AUC/MIC ratio
Vancomycin efficacy is best predicted by the AUC/MIC ratio, with a target AUC24/MIC ≥400 recommended by current guidelines.
When preparing a sterile IV admixture in a horizontal laminar airflow workbench (LAFW), the pharmacist should work at least how far inside the hood?
Answer: 6 inches
USP requires that all critical manipulations be performed at least 6 inches inside the LAFW to ensure sterile airflow protection.
A patient on warfarin is started on fluconazole. What INR monitoring adjustment is most appropriate?
Answer: Check INR more frequently and adjust warfarin based on results
Fluconazole inhibits CYP2C9 and significantly increases warfarin levels, so more frequent INR monitoring with dose adjustment is required.
Which of the following is the correct procedure for reconstituting a lyophilized powder for injection?
Answer: Direct the diluent stream against the vial wall
Directing diluent against the vial wall prevents foaming and protein denaturation, ensuring proper reconstitution.
A 70 kg patient with a creatinine clearance of 15 mL/min requires gentamicin. Which dosing strategy is most appropriate?
Answer: Reduced dose at extended interval
Severe renal impairment requires both dose reduction and interval extension for aminoglycosides to prevent accumulation and nephrotoxicity.
During a medication use evaluation (MUE), what is the PRIMARY purpose of establishing criteria before data collection?
Answer: To ensure unbiased, objective assessment of drug therapy
Pre-established criteria ensure that the evaluation is objective and unbiased, forming the benchmark against which actual practice is measured.
A nurse reports that a patient's IV line has become infiltrated during a vesicant infusion. What is the pharmacist's FIRST recommended action?
Answer: Stop the infusion and disconnect the IV tubing
The first step is to stop the infusion immediately and disconnect tubing to prevent further extravasation of the vesicant agent.