IBHRE Pharmacology and Drug Therapy 2

Question 1

Why does dofetilide require mandatory 3-day in-hospital initiation?

Accepted Answer

Risk of QT prolongation and torsades de pointes

Answer

Risk of severe bradycardia

Answer

Risk of hypertensive crisis

Answer

Risk of acute renal failure

Question 2

Which antiarrhythmic drug requires regular monitoring of thyroid and pulmonary function due to its molecular structure?

Accepted Answer

Amiodarone

Answer

Sotalol

Answer

Flecainide

Answer

Dronedarone

Question 3

Sotalol combines the pharmacological actions of which two Vaughan Williams classes?

Accepted Answer

Class II and Class III

Answer

Class I and Class IV

Answer

Class I and Class II

Answer

Class III and Class IV

Question 4

Ranolazine's antiarrhythmic properties are primarily due to inhibition of which sodium current?

Accepted Answer

Late INa

Answer

Peak INa

Answer

IKr

Answer

IKs

Question 5

Which drug should be avoided in Wolff-Parkinson-White syndrome with atrial fibrillation because it enhances accessory pathway conduction?

Accepted Answer

Digoxin

Answer

Flecainide

Answer

Procainamide

Answer

Amiodarone

Question 6

How does dronedarone structurally differ from amiodarone?

Accepted Answer

It is non-iodinated

Answer

It has higher iodine content

Answer

It has a longer half-life

Answer

It is a pure beta-blocker