FANZCA FANZCA Clinical Pharmacology and Anesthesia 3

Question 1

Which opioid analgesic has an active metabolite (morphine-6-glucuronide) that accumulates in renal failure and can cause prolonged respiratory depression?

Accepted Answer

Morphine

Answer

Fentanyl

Answer

Remifentanil

Answer

Alfentanil

Question 2

What is neostigmine's mechanism for reversing non-depolarizing neuromuscular blockade?

Accepted Answer

Inhibition of acetylcholinesterase, increasing synaptic acetylcholine to compete with the blocker

Answer

Direct agonism at nicotinic acetylcholine receptors

Answer

Encapsulation of the neuromuscular blocking drug molecule

Answer

Blockade of voltage-gated calcium channels at the motor end plate

Question 3

Which benzodiazepine is preferred for procedural sedation in anesthesia due to its short duration, amnesic properties, and water solubility?

Accepted Answer

Midazolam

Answer

Diazepam

Answer

Lorazepam

Answer

Clonazepam

Question 4

What is the primary advantage of remifentanil over other opioids for total intravenous anesthesia (TIVA)?

Accepted Answer

It is metabolized by plasma esterases, giving a predictably short context-sensitive half-time regardless of infusion length

Answer

It can be administered orally for premedication

Answer

It has no effect on the respiratory system

Answer

It produces prolonged postoperative analgesia

Question 5

Which drug is used as a specific reversal agent for benzodiazepine-induced sedation and respiratory depression in the perioperative setting?

Accepted Answer

Flumazenil

Answer

Naloxone

Answer

Neostigmine

Answer

Physostigmine

Question 6

Which vasopressor used in anesthesia acts primarily through alpha-1 adrenoceptor agonism to treat anesthesia-induced hypotension without causing significant tachycardia?

Accepted Answer

Phenylephrine

Answer

Ephedrine

Answer

Dopamine

Answer

Dobutamine