FANZCA FANZCA Clinical Pharmacology and Anesthesia 2

Question 1

Which pharmacodynamic parameter describes the concentration of a drug required to produce 50% of its maximum effect?

Accepted Answer

EC50

Answer

LD50

Answer

Vd

Answer

Tmax

Question 2

What is the primary mechanism by which ketamine produces dissociative anesthesia?

Accepted Answer

NMDA receptor antagonism

Answer

GABA-A receptor potentiation

Answer

Alpha-2 adrenoceptor agonism

Answer

Mu-opioid receptor agonism

Question 3

Which inhalational agent is contraindicated in patients with a known or suspected genetic predisposition to malignant hyperthermia?

Accepted Answer

All potent volatile halogenated agents

Answer

Nitrous oxide

Answer

Xenon

Answer

Sevoflurane

Question 4

What is the clinical significance of the context-sensitive half-time in intravenous anesthetic pharmacokinetics?

Accepted Answer

It represents the half-life of a drug after infusion ceases, which increases with longer infusions for many drugs

Answer

It predicts how fast a drug is absorbed from the gut

Answer

It describes the time to peak plasma concentration after a bolus

Answer

It reflects the drug's volume of distribution at steady state

Question 5

Which drug class used in anesthesia acts by inhibiting cyclooxygenase enzymes to provide multimodal analgesia as part of an opioid-sparing strategy?

Accepted Answer

NSAIDs

Answer

Benzodiazepines

Answer

Alpha-2 agonists

Answer

N-methyl-D-aspartate antagonists

Question 6

What is the pharmacological rationale for using dexmedetomidine as a sedative in the ICU or as an adjunct in anesthesia?

Accepted Answer

It selectively activates alpha-2 adrenoceptors to produce sedation, analgesia, and anxiolysis without significant respiratory depression

Answer

It enhances GABA-mediated inhibition in the cortex

Answer

It blocks dopamine D2 receptors to reduce agitation

Answer

It inhibits histamine H1 receptors causing sedation