FANZCA FANZCA Clinical Pharmacology and Anesthesia

Question 1

Which volatile anesthetic agent has the lowest blood-gas partition coefficient, resulting in the fastest induction and emergence?

Accepted Answer

Desflurane

Answer

Sevoflurane

Answer

Isoflurane

Answer

Halothane

Question 2

What is the mechanism of action of succinylcholine as a neuromuscular blocking agent?

Accepted Answer

Depolarizing agonism at nicotinic acetylcholine receptors

Answer

Competitive antagonism at nicotinic acetylcholine receptors

Answer

Inhibition of acetylcholinesterase at the neuromuscular junction

Answer

Blockade of voltage-gated sodium channels in motor neurons

Question 3

Which opioid is most commonly associated with chest wall rigidity ('wooden chest syndrome') when administered rapidly in high doses?

Accepted Answer

Fentanyl

Answer

Morphine

Answer

Hydromorphone

Answer

Codeine

Question 4

What is the primary reason propofol produces pain on injection when administered through a peripheral IV?

Accepted Answer

Its lipid emulsion vehicle activates bradykinin and free nerve endings

Answer

Its highly alkaline pH irritates the vein

Answer

It causes direct endothelial histamine release

Answer

Its high osmolality damages vessel walls

Question 5

Which reversal agent is used to antagonize non-depolarizing neuromuscular blockers by forming a tight inclusion complex, specifically targeting rocuronium and vecuronium?

Accepted Answer

Sugammadex

Answer

Neostigmine

Answer

Pyridostigmine

Answer

Edrophonium

Question 6

Which local anesthetic is most associated with cardiotoxicity and has a narrow therapeutic window compared to newer long-acting agents?

Accepted Answer

Bupivacaine

Answer

Ropivacaine

Answer

Levobupivacaine

Answer

Lidocaine