DDS Oral Pathology and Oral Medicine 3

Question 1

Pemphigus vulgaris involves oral mucosa due to autoantibodies directed against:

Accepted Answer

Desmoglein-3 (desmosomal adhesion protein)

Answer

Laminin-332 at the basement membrane

Answer

BP180 (type XVII collagen) at the hemidesmosome

Answer

Fibronectin in the connective tissue

Question 2

Which feature most distinguishes odontogenic keratocyst from other jaw cysts histologically?

Accepted Answer

Thin corrugated parakeratinized epithelium with a basal cell layer showing palisading

Answer

Thick fibrous wall with cholesterol clefts

Answer

Mucous cells within the cyst lining

Answer

Extensive inflammatory infiltrate with Rushton bodies

Question 3

Fordyce spots in the oral cavity represent:

Accepted Answer

Ectopic sebaceous glands in the oral mucosa

Answer

Accessory parotid gland tissue

Answer

Early leukoplakia

Answer

Lymphoid aggregates in the mucosa

Question 4

Necrotizing ulcerative gingivitis (NUG) is caused by synergistic infection involving which organisms?

Accepted Answer

Spirochetes (Treponema) and fusiform bacteria (Fusobacterium nucleatum)

Answer

Streptococcus mutans and Lactobacillus acidophilus

Answer

Actinomyces israelii and Candida albicans

Answer

Porphyromonas gingivalis alone

Question 5

Geographic tongue (benign migratory glossitis) is characterized by:

Accepted Answer

Migratory areas of erythema surrounded by a white keratotic border that change over days

Answer

Permanent depapillation with no healing capacity

Answer

Painful vesicular eruption limited to the dorsal tongue

Answer

Hyperplasia of filiform papillae causing hairy tongue appearance

Question 6

Which histopathologic finding is pathognomonic for herpes simplex virus infection in oral epithelium?

Accepted Answer

Multinucleated giant cells with intranuclear inclusions (Cowdry type A)

Answer

Koilocytes with perinuclear halos

Answer

Dowling bodies in the basal layer

Answer

Acantholytic cells (Tzanck cells) without inclusions