Practice Test Geeks(CTP) Certified Transplant Preservationist Practice Test
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Organ Preservation Techniques Flashcards

7 cards from real CTP practice questions. Tap to flip, then mark Knew It or Still Learning — missed cards come back until you master them.

Read the first 7 Organ Preservation Techniques flashcards as text

  1. What is the role of prostaglandin E1 (PGE1) in lung preservation during procurement?

    Answer: Pulmonary vasodilation to ensure uniform distribution of flush solution

    PGE1 is administered before lung flush to dilate the pulmonary vasculature, ensuring uniform distribution of cold preservation solution throughout the lungs.

  2. In normothermic regional perfusion (NRP) for DCD donors, what is the primary goal of excluding the cerebral circulation?

    Answer: To prevent restoration of brain perfusion in a legally dead donor

    Cerebral vessels are ligated or clamped during NRP to ensure no blood flow is restored to the brain, preserving the legal and ethical basis of death determination.

  3. Which preservation solution is most commonly used for small bowel transplantation due to its ability to limit mucosal injury?

    Answer: University of Wisconsin (UW) solution

    UW solution is the standard for small bowel preservation, providing optimal protection for the ischemia-sensitive intestinal mucosa.

  4. Which parameter measured during hypothermic machine perfusion (HMP) of a kidney indicates vascular damage that predicts poor graft outcome?

    Answer: Persistently elevated resistive index (RI > 0.4)

    A persistently high RI during HMP indicates irreversible vascular damage and is associated with increased risk of delayed graft function or non-function.

  5. What is the primary metabolic substrate provided to organs during normothermic machine perfusion (NMP) to support aerobic metabolism?

    Answer: Red blood cells as oxygen carriers combined with glucose

    NMP perfusate contains packed red blood cells to carry oxygen and glucose as the primary energy substrate to sustain aerobic cellular metabolism.

  6. During cold static storage, at what temperature range is organ preservation most effective?

    Answer: 0–4°C

    Storage at 0–4°C reduces cellular metabolic rate by approximately 12-fold compared to body temperature, significantly slowing ischemic injury.

  7. Which condition is most likely to occur if a kidney is stored in preservation solution at temperatures below 0°C?

    Answer: Ice crystal formation causing irreversible cellular membrane damage

    Freezing causes intracellular and extracellular ice crystal formation that physically disrupts cell membranes, leading to irreversible injury.