Research Methods & Evidence-Based Practice Flashcards
7 cards from real CSR practice questions. Tap to flip, then mark Knew It or Still Learning — missed cards come back until you master them.
Read the first 7 Research Methods & Evidence-Based Practice flashcards as text
In a randomized controlled trial evaluating a low-phosphorus diet in CKD patients, the primary outcome is serum phosphorus reduction. What is the most appropriate method to account for dropouts and maintain the integrity of the original randomization?
Answer: Intention-to-treat analysis
Intention-to-treat analysis preserves randomization and prevents bias introduced by selective dropout, making it the gold standard for RCT primary outcomes.
A renal dietitian wants to evaluate the strength of a study's causal claim that dietary protein restriction slows GFR decline. Which study design provides the highest level of evidence for causality?
Answer: Systematic review of randomized controlled trials
A systematic review of RCTs sits at the top of the evidence hierarchy and provides the strongest basis for causal inferences.
When appraising a meta-analysis on potassium intake in dialysis patients, a renal dietitian notices an I² statistic of 85%. How should this be interpreted?
Answer: There is high heterogeneity among the included studies
An I² of 75% or higher indicates substantial to considerable heterogeneity, suggesting the studies are measuring the intervention effect under very different conditions.
A dietitian is designing a study comparing intradialytic parenteral nutrition (IDPN) versus oral supplements on albumin levels. Which blinding strategy is most feasible in this setting?
Answer: Single-blind (only outcome assessor blinded)
Because patients can identify their nutritional delivery route, blinding only the outcome assessor (single-blind) is the most feasible rigorous option.
In a renal nutrition study, researchers report a statistically significant result (p=0.03) but a mean serum phosphorus reduction of only 0.2 mg/dL. What concept best explains why this finding may not be clinically meaningful?
Answer: Difference between statistical and clinical significance
Statistical significance indicates a result unlikely due to chance, but clinical significance requires the effect size to be large enough to matter in patient care.
A cross-sectional study finds that hemodialysis patients with higher dietary sodium intake have higher blood pressure. Which limitation is most critical when interpreting this finding?
Answer: Cannot establish temporal relationship between sodium and blood pressure
Cross-sectional studies measure exposure and outcome simultaneously, making it impossible to determine which came first or establish causality.
A renal dietitian is using the GRADE framework to assess evidence quality for a guideline recommendation on dietary potassium restriction in CKD stage 4. Which factor would DOWNGRADE the quality of evidence?
Answer: Serious risk of bias in included studies
In GRADE, serious risk of bias in the included studies is a primary reason to downgrade the overall certainty of evidence.