CSR Pharmacology & Drug-Nutrient Interactions in Renal Disease Flashcards
6 cards from real CSR practice questions. Tap to flip, then mark Knew It or Still Learning — missed cards come back until you master them.
Read the first 6 CSR Pharmacology & Drug-Nutrient Interactions in Renal Disease flashcards as text
Vitamin C supplementation exceeding 100 mg/day in CKD patients increases the risk of accumulation of which substance?
Answer: Oxalate
Excess vitamin C is metabolized to oxalate, which can accumulate dangerously in CKD patients with reduced excretion capacity.
Which drug used for secondary hyperparathyroidism requires regular serum calcium monitoring to detect hypocalcemia?
Answer: Cinacalcet
Cinacalcet suppresses PTH secretion and can cause hypocalcemia by over-activating the calcium-sensing receptor.
Metformin is generally contraindicated in CKD patients with an eGFR below which threshold due to lactic acidosis risk?
Answer: 30 mL/min/1.73m²
Metformin is contraindicated below eGFR 30 because drug accumulation significantly raises the risk of lactic acidosis.
Which potassium-sparing diuretic is typically avoided in CKD patients due to increased risk of hyperkalemia?
Answer: Spironolactone
Spironolactone blocks aldosterone, reducing potassium excretion and worsening hyperkalemia in CKD patients.
Iron deficiency in CKD patients receiving ESA therapy is typically defined by transferrin saturation (TSAT) below what level?
Answer: 20%
Functional iron deficiency in ESA-treated CKD patients is defined as TSAT below 20% per clinical guidelines.
Which phosphate binder is a polymer-based, non-calcium, non-metal agent that also helps lower LDL cholesterol?
Answer: Sevelamer carbonate
Sevelamer carbonate is a non-absorbed polymer that binds phosphate and also reduces LDL cholesterol as a secondary benefit.