CSR Pharmacology & Drug-Nutrient Interactions in Renal Disease Flashcards
6 cards from real CSR practice questions. Tap to flip, then mark Knew It or Still Learning — missed cards come back until you master them.
Read the first 6 CSR Pharmacology & Drug-Nutrient Interactions in Renal Disease flashcards as text
Cinacalcet (a calcimimetic) lowers PTH levels by activating which receptor on parathyroid gland cells?
Answer: Calcium-sensing receptor (CaSR)
Cinacalcet activates the calcium-sensing receptor on parathyroid cells, suppressing PTH secretion.
Which adverse electrolyte effect is associated with the potassium binder patiromer due to nonselective GI binding?
Answer: Hypomagnesemia
Patiromer can bind magnesium in the GI tract in addition to potassium, leading to hypomagnesemia.
Which antibiotic class requires significant dose reduction in CKD because it is renally cleared and nephrotoxic?
Answer: Aminoglycosides
Aminoglycosides are renally cleared and intrinsically nephrotoxic, requiring dose adjustment to prevent accumulation in CKD.
Sodium bicarbonate supplementation in CKD is primarily used to treat which acid-base disturbance?
Answer: Metabolic acidosis
Sodium bicarbonate corrects metabolic acidosis, which is common in advanced CKD due to reduced renal acid excretion.
Which phosphate binder contains iron as its active binding component and may contribute to iron stores?
Answer: Sucroferric oxyhydroxide
Sucroferric oxyhydroxide is an iron-based phosphate binder that can also provide some iron supplementation benefit.
Why must warfarin dosing be carefully managed alongside dietary vitamin K in CKD patients?
Answer: Renal disease alters warfarin metabolism and vitamin K-dependent clotting factors
CKD alters drug clearance and clotting factor synthesis, making warfarin response unpredictable and requiring careful vitamin K monitoring.