CSMLS CSMLS Immunology and Serology

Question 1

Which immunoglobulin class is the first to be produced during a primary immune response?

Accepted Answer

IgM

Answer

IgG

Answer

IgA

Answer

IgE

Question 2

In an enzyme-linked immunosorbent assay (ELISA), the signal is generated by:

Accepted Answer

An enzyme conjugated to an antibody

Answer

A radioactive isotope

Answer

A fluorescent dye attached to antigen

Answer

A complement protein

Question 3

The complement pathway initiated by antigen-antibody complexes is the:

Accepted Answer

Classical pathway

Answer

Lectin pathway

Answer

Alternative pathway

Answer

Propyl pathway

Question 4

A prozone phenomenon in agglutination testing occurs when:

Accepted Answer

Antibody is in excess causing false-negative results

Answer

Antigen is in excess causing false-negative results

Answer

Temperature is too high

Answer

pH is too acidic

Question 5

Which serological test is the gold standard for confirming HIV infection?

Accepted Answer

Western blot

Answer

ELISA

Answer

Latex agglutination

Answer

Immunofluorescence

Question 6

HLA typing in transplantation medicine is performed to:

Accepted Answer

Match donor and recipient tissue antigens to reduce rejection

Answer

Detect blood group antigens

Answer

Identify ABO incompatibility

Answer

Screen for autoimmune disease