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Pharmacology of Sedative Agents Flashcards

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  1. Which of the following best describes the concept of drug synergy in conscious sedation?

    Answer: Combined drugs produce an effect greater than the sum of each individually

    Synergy means the combined effect exceeds additive effect; opioid-benzodiazepine combinations, for example, markedly increase respiratory depression risk.

  2. The recommended initial IV dose of midazolam for adult conscious sedation is:

    Answer: 0.5–1 mg, titrated slowly

    Adult midazolam dosing for conscious sedation starts at 0.5–1 mg IV, titrated slowly to effect to minimize oversedation.

  3. Which class of drugs used in sedation can cause emergence reactions characterized by vivid dreams or hallucinations?

    Answer: Dissociative agents (ketamine)

    Ketamine is well known for causing emergence reactions including vivid dreams, delirium, and hallucinations during recovery from sedation.

  4. Which of the following best describes the redistribution phenomenon relevant to propofol's short clinical duration?

    Answer: Propofol redistributes from the brain to peripheral tissues, ending its effect

    Propofol's short clinical duration is primarily due to rapid redistribution from the highly vascular brain to peripheral fat and muscle tissues.

  5. A nurse administering fentanyl notices the patient's chest wall rigidity preventing ventilation. This is known as:

    Answer: Wooden chest syndrome

    Wooden chest (chest wall rigidity) is a dose-dependent complication of high-dose or rapidly administered fentanyl, impairing manual ventilation.

  6. Dexmedetomidine exerts its sedative and analgesic effects by acting on which receptor subtype?

    Answer: Alpha-2 adrenergic receptors

    Dexmedetomidine is a selective alpha-2 adrenergic agonist that acts centrally in the locus coeruleus to produce sedation, anxiolysis, and analgesia.

  7. Which of the following is a common adverse effect of rapid propofol administration?

    Answer: Hypotension and apnea

    Rapid propofol boluses commonly cause transient hypotension (vasodilation) and apnea, requiring careful titration and airway readiness.