Practice Test Geeks(CPI) Certified Physician Investigator Practice Test
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Infection Control & Prevention Flashcards

7 cards from real CPI practice questions. Tap to flip, then mark Knew It or Still Learning — missed cards come back until you master them.

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  1. A Certified Physician Investigator is reviewing a protocol involving bronchoscopy procedures. Which transmission-based precaution is most appropriate during this aerosol-generating procedure?

    Answer: Airborne Precautions

    Bronchoscopy is an aerosol-generating procedure requiring Airborne Precautions, including N95 respirator use and negative-pressure room when feasible.

  2. Which regulatory body in the US sets standards for occupational exposure to blood-borne pathogens in research settings?

    Answer: OSHA

    OSHA's Bloodborne Pathogens Standard (29 CFR 1910.1030) mandates employer protections for workers with occupational exposure to blood-borne pathogens.

  3. A trial site is conducting a study involving participants with active pulmonary tuberculosis. Staff entering participant rooms should wear at minimum a:

    Answer: N95 filtering facepiece respirator

    An N95 respirator is the minimum respiratory protection required for entering rooms of patients with suspected or confirmed pulmonary TB.

  4. Which of the following disinfection methods achieves the HIGHEST level of disinfection short of sterilization?

    Answer: High-level disinfection with glutaraldehyde

    High-level disinfection with glutaraldehyde or other high-level disinfectants destroys all microorganisms except high numbers of bacterial spores.

  5. An investigator conducting a vaccine trial must report a cluster of injection-site abscesses in participants. This is BEST classified as a:

    Answer: Serious adverse event requiring expedited reporting

    A cluster of injection-site abscesses is a serious adverse event potentially linked to the investigational product or technique and requires expedited reporting.

  6. In a multi-site clinical trial, one site reports an unusually high rate of surgical site infections (SSIs). The FIRST step in investigation should be:

    Answer: Conduct a root cause analysis of aseptic technique and processes

    Root cause analysis of procedural technique, sterility practices, and environmental factors is the first step to identify and correct the source of excess SSIs.

  7. Which type of clinical trial participant population requires the MOST stringent infection prevention measures due to impaired host defenses?

    Answer: Hematopoietic stem cell transplant recipients

    Hematopoietic stem cell transplant recipients have profoundly impaired immunity and are at extreme risk for opportunistic infections, requiring the strictest protective measures.