Compounding Flashcards
7 cards from real CPHT practice questions. Tap to flip, then mark Knew It or Still Learning — missed cards come back until you master them.
Read the first 7 Compounding flashcards as text
According to USP , which of the following is classified as a hazardous drug (HD) requiring special handling?
Answer: Cyclophosphamide injection
Cyclophosphamide is an antineoplastic agent on the NIOSH HD list requiring containment, PPE, and dedicated compounding areas.
A technician is compounding a preparation that requires geometric dilution. What is the correct technique?
Answer: Combine equal parts of the most potent ingredient with the diluent, then add successive equal portions
Geometric dilution ensures uniform mixing of a potent drug by repeatedly doubling the quantity with diluent rather than adding it all at once.
What is the purpose of a 'certificate of analysis' (COA) when procuring bulk drug substances for compounding?
Answer: It documents identity, purity, potency, and sterility test results for the raw ingredient
A COA from the manufacturer or third-party lab confirms the active pharmaceutical ingredient meets stated specifications before use in compounding.
An otic solution is compounded using propylene glycol as the vehicle. Which property of propylene glycol makes it suitable for this route?
Answer: It is hygroscopic and helps remove moisture from the ear canal
Propylene glycol is hygroscopic, drawing moisture away from the ear canal environment, which is beneficial in treating conditions such as swimmer's ear.
Which of the following compounding records must be retained according to USP and most state boards of pharmacy?
Answer: Both the master formulation record and the compounding record for each batch
The master formulation record (formula and procedure) and a compounding record for each preparation (lot, quantities, compounder identity) are both required.
When compounding a preparation with a drug that has a narrow therapeutic index, which quality control step is MOST important?
Answer: Conducting or obtaining an independent weight verification
For narrow-therapeutic-index drugs, an independent double-check of the weight ensures the dose is accurate, because small errors can cause toxicity or therapeutic failure.
A 503A pharmacy may compound which of the following WITHOUT a patient-specific prescription?
Answer: Anticipatory compounding in limited quantities based on historical prescribing patterns
503A pharmacies may prepare a small supply of a compounded preparation in anticipation of prescriptions based on documented history of such prescriptions.