Pharmacology Fundamentals Flashcards
7 cards from real COKO practice questions. Tap to flip, then mark Knew It or Still Learning — missed cards come back until you master them.
Read the first 7 Pharmacology Fundamentals flashcards as text
A client is prescribed nitroglycerin for angina. How does this drug primarily reduce cardiac workload?
Answer: By dilating veins to reduce preload
Nitroglycerin releases nitric oxide, causing venous dilation that reduces venous return (preload) and decreases myocardial oxygen demand.
Which receptor type mediates the 'fight-or-flight' cardiovascular response relevant to exercise physiology?
Answer: Beta-1 adrenergic receptors
Beta-1 adrenergic receptors in the heart mediate increased heart rate and contractility in response to catecholamines during exercise.
A post-surgical client is prescribed an opioid analgesic. Which side effect is most relevant when planning early mobilization?
Answer: Sedation and dizziness increasing fall risk
Opioids cause CNS depression including sedation and postural instability, significantly increasing fall risk during ambulation.
Drug tolerance develops when repeated use of a drug results in:
Answer: A diminished response requiring higher doses for the same effect
Tolerance is the reduction in drug effect with repeated administration, requiring dose escalation to maintain the same therapeutic response.
A client taking SSRIs for depression joins an exercise program. Which pharmacological consideration is most important for the kinesiologist?
Answer: Increased bleeding risk due to platelet serotonin depletion
SSRIs deplete platelet serotonin stores, impairing platelet aggregation and increasing bleeding risk, particularly with high-impact activities.
Which pharmacokinetic process determines how quickly a drug reaches systemic circulation after oral administration?
Answer: Absorption
Absorption from the gastrointestinal tract determines the rate and extent to which an orally administered drug enters systemic circulation.
A client with osteoporosis is prescribed bisphosphonates. The kinesiologist should know these drugs work primarily by:
Answer: Inhibiting osteoclast-mediated bone resorption
Bisphosphonates inhibit osteoclasts, reducing bone resorption and helping to maintain or improve bone mineral density.