CMI CMI Pathology & Disease Processes

Question 1

Which cellular change is characteristic of irreversible cell injury leading to necrosis?

Accepted Answer

Nuclear pyknosis

Answer

Membrane blebbing

Answer

Ribosomal disaggregation

Answer

Mitochondrial swelling

Question 2

In illustrating atherosclerosis, which layer of the arterial wall does the fatty streak primarily involve?

Accepted Answer

Tunica intima

Answer

Tunica adventitia

Answer

Tunica media

Answer

Elastic lamina

Question 3

Which type of necrosis is most associated with liquefaction in brain infarcts?

Accepted Answer

Liquefactive necrosis

Answer

Coagulative necrosis

Answer

Caseous necrosis

Answer

Fat necrosis

Question 4

When depicting tumor angiogenesis, which growth factor is the primary driver of new vessel formation?

Accepted Answer

VEGF

Answer

EGF

Answer

TGF-β

Answer

PDGF

Question 5

Apoptotic cells are best identified histologically by which feature?

Accepted Answer

Apoptotic bodies with condensed chromatin

Answer

Ghost cell outlines

Answer

Inflammatory infiltrate

Answer

Nuclear karyolysis

Question 6

In illustrating Crohn's disease, which transmural feature distinguishes it from ulcerative colitis?

Accepted Answer

Skip lesions with granulomas

Answer

Pseudopolyps

Answer

Crypt abscesses

Answer

Continuous mucosal involvement