Organ & Tissue Allocation Flashcards
6 cards from real CHT practice questions. Tap to flip, then mark Knew It or Still Learning — missed cards come back until you master them.
Read the first 6 Organ & Tissue Allocation flashcards as text
What is the Kidney Donor Profile Index (KDPI) used for in organ allocation?
Answer: Estimating the relative risk of graft failure from a deceased donor kidney compared to the average donor
KDPI uses 10 donor characteristics to estimate a percentile ranking of graft failure risk, helping recipients and transplant teams make informed decisions about marginal-quality organs.
Which factor does NOT directly influence a kidney recipient's waiting time priority under current UNOS policy?
Answer: Recipient's socioeconomic status
UNOS allocation policy explicitly prohibits socioeconomic status from being a factor; priority is based on medical/immunological criteria, time waiting, and geographic factors.
What is 'machine perfusion' of donor kidneys designed to accomplish?
Answer: Maintain kidney viability and allow assessment of organ function before transplant by continuously perfusing with solution
Hypothermic machine perfusion maintains renal viability during preservation, reduces delayed graft function rates, and allows perfusate biomarker assessment of organ quality.
In tissue banking, which regulatory body regulates human cells, tissues, and cellular/tissue-based products (HCT/Ps) in the US?
Answer: FDA (Food and Drug Administration)
The FDA regulates human cells, tissues, and cellular/tissue-based products under 21 CFR Part 1271 to prevent transmission of communicable diseases and ensure safety.
What is the significance of ABO blood group compatibility in solid organ transplantation?
Answer: ABO-incompatible transplants risk hyperacute rejection from natural anti-A/anti-B antibodies and require desensitization
Natural anti-A and anti-B antibodies (IgM and IgG) are present in most individuals and can cause hyperacute rejection of ABO-incompatible solid organs by attacking vascular endothelium.
Which allocation principle ensures that the sickest patients (greatest medical urgency) receive priority for certain organs like hearts and livers?
Answer: Medical urgency status (e.g., Status 1A/1B for hearts, MELD score for livers)
Hearts and livers use medical urgency scoring (Status 1A/1B and MELD/PELD respectively) so that the most critically ill patients on life support or near death receive priority.