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Organ & Tissue Allocation Flashcards

6 cards from real CHT practice questions. Tap to flip, then mark Knew It or Still Learning — missed cards come back until you master them.

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  1. What is a 'zero-antigen mismatch' kidney in UNOS allocation policy?

    Answer: A kidney with no mismatches at HLA-A, -B, and -DR compared to the recipient

    Zero-antigen mismatch (0-MM) kidneys have no mismatches at HLA-A, -B, and -DR antigens between donor and recipient and are shared nationally under UNOS policy due to superior outcomes.

  2. Which organ has the shortest clinically acceptable cold ischemia time, requiring the fastest allocation decisions?

    Answer: Heart

    Hearts have a cold ischemia tolerance of only 4–6 hours, requiring rapid allocation and transportation to minimize ischemic injury.

  3. In the context of living donor kidney transplantation, what is a 'paired kidney exchange' program?

    Answer: Incompatible donor-recipient pairs swap donors with other incompatible pairs to create compatible matches

    Kidney paired donation matches incompatible living donor-recipient pairs with other pairs so that each donor gives to a compatible recipient from another pair.

  4. What does 'cold ischemia time' refer to in organ transplantation?

    Answer: The time from organ cooling/flushing at procurement until the clamp is removed and blood flow is restored in the recipient

    Cold ischemia time begins when the organ is flushed with cold preservation solution and ends at reperfusion in the recipient, representing the total ischemic insult during hypothermic storage.

  5. Which US law established the framework for organ transplantation, prohibited organ sales, and created the OPTN?

    Answer: National Organ Transplant Act (NOTA) of 1984

    NOTA established the legal framework for transplantation in the US, created the OPTN, prohibited the sale of organs, and mandated equitable organ sharing.

  6. What is the primary purpose of HLA typing in the context of deceased donor organ allocation?

    Answer: To identify compatible recipients, perform virtual crossmatches, and prioritize zero-mismatch candidates

    Rapid deceased donor HLA typing allows the allocation center to identify compatible candidates, perform virtual crossmatches, flag DSA concerns, and apply zero-mismatch priority rules.