ASCP Transfusion Medicine

Question 1

Which ABO blood group is considered the 'universal donor' for red blood cell transfusions?

Accepted Answer

Group O

Answer

Group A

Answer

Group B

Answer

Group AB

Question 2

The indirect antiglobulin test (IAT or indirect Coombs test) detects:

Accepted Answer

Unexpected antibodies in patient serum that react with reagent red cells in vitro

Answer

Antibodies already coating red cells in vivo

Answer

ABO forward grouping

Answer

Platelet antibodies

Question 3

Hemolytic disease of the fetus and newborn (HDFN) caused by anti-D requires all of the following EXCEPT:

Accepted Answer

ABO incompatibility between mother and fetus

Answer

D-negative mother

Answer

D-positive fetus

Answer

Maternal IgG anti-D crossing the placenta

Question 4

Which blood product is most appropriate for a patient with isolated thrombocytopenia (platelet count 15,000/µL) and active bleeding?

Accepted Answer

Apheresis platelets (single donor)

Answer

Fresh frozen plasma (FFP)

Answer

Cryoprecipitate

Answer

Packed red blood cells

Question 5

A positive direct antiglobulin test (DAT) combined with a positive elution study suggests:

Accepted Answer

Warm autoimmune hemolytic anemia (WAIHA) or alloantibody causing hemolysis

Answer

ABO incompatibility in typing only

Answer

Factor deficiency

Answer

Normal newborn screening result

Question 6

TACO (transfusion-associated circulatory overload) is best distinguished from TRALI (transfusion-related acute lung injury) by:

Accepted Answer

Response to diuretics and elevated BNP in TACO versus normal filling pressures in TRALI

Answer

Time of onset after transfusion

Answer

Presence of fever

Answer

Blood product type implicated