ASCP Immunology and Serology

Question 1

The VDRL and RPR tests are nontreponemal screening tests for which disease?

Accepted Answer

Syphilis

Answer

Lyme disease

Answer

HIV infection

Answer

Hepatitis B

Question 2

Which immunoglobulin class is the first produced in a primary immune response?

Accepted Answer

IgM

Answer

IgG

Answer

IgA

Answer

IgE

Question 3

A positive ANA (antinuclear antibody) test is most associated with which autoimmune disease?

Accepted Answer

Systemic lupus erythematosus (SLE)

Answer

Rheumatoid arthritis

Answer

Ankylosing spondylitis

Answer

Sjögren's syndrome alone

Question 4

ELISA (enzyme-linked immunosorbent assay) is used as the initial test for HIV diagnosis because:

Accepted Answer

It has high sensitivity to minimize false negatives

Answer

It is the most specific test available

Answer

It can detect viral RNA directly

Answer

It requires no confirmatory testing

Question 5

Rheumatoid factor (RF) is an antibody directed against:

Accepted Answer

The Fc portion of IgG

Answer

Double-stranded DNA

Answer

Cyclic citrullinated peptides

Answer

Cardiolipin

Question 6

Which hepatitis B marker indicates active viral replication and high infectivity?

Accepted Answer

HBeAg

Answer

HBsAg alone

Answer

Anti-HBs

Answer

Anti-HBc IgG