ASCP Clinical Microscopy 3

Question 1

Massive calcium oxalate crystalluria in a patient with high anion gap metabolic acidosis is most concerning for:

Accepted Answer

Ethylene glycol poisoning

Answer

Normal diet high in oxalate foods

Answer

Alkaline urine artifact

Answer

Cystinuria

Question 2

Döhle bodies in neutrophils on a peripheral blood smear are most commonly seen in:

Accepted Answer

Severe infections, burns, or toxic states

Answer

Iron deficiency anemia

Answer

Pernicious anemia

Answer

Polycythemia vera

Question 3

Which finding on urine microscopy is pathognomonic (diagnostic) of glomerulonephritis?

Accepted Answer

Red blood cell casts

Answer

Granular casts

Answer

White blood cell casts

Answer

Hyaline casts

Question 4

On a stained bone marrow aspirate, a plasma cell is identified by which morphological features?

Accepted Answer

Eccentric nucleus with clock-face chromatin and basophilic cytoplasm with perinuclear hof (clearing)

Answer

Bilobed nucleus and large purple granules

Answer

Large irregular nucleus with prominent nucleoli and scant cytoplasm

Answer

Multilobed nucleus with pale cytoplasm

Question 5

Trichomonas vaginalis on a wet prep (saline mount) is identified by:

Accepted Answer

Motile, pear-shaped flagellated organisms with jerky tumbling motility

Answer

Cysts with 4 nuclei

Answer

Gram-negative diplococci within WBCs

Answer

Pseudohyphae with budding yeast

Question 6

A CSF sample from a patient with suspected cryptococcal meningitis should have which test performed immediately?

Accepted Answer

India ink preparation and cryptococcal antigen (CrAg) latex agglutination

Answer

PCR for HSV

Answer

Gram stain for bacteria only

Answer

AFB smear for tuberculosis