AOA AOA Pharmacology and Therapeutics

Question 1

Which medication class is considered first-line pharmacological therapy for type 2 diabetes mellitus?

Accepted Answer

Metformin (biguanide)

Answer

Sulfonylureas

Answer

Insulin

Answer

DPP-4 inhibitors

Question 2

What is the mechanism of action of ACE inhibitors in treating hypertension?

Accepted Answer

Inhibit conversion of angiotensin I to angiotensin II

Answer

Block calcium channels in vascular smooth muscle

Answer

Block beta-adrenergic receptors in the heart

Answer

Promote sodium excretion in the distal tubule

Question 3

Which antibiotic class is contraindicated in pregnant women due to risk of fetal dental discoloration and impaired bone growth?

Accepted Answer

Tetracyclines

Answer

Penicillins

Answer

Cephalosporins

Answer

Macrolides

Question 4

What is the primary therapeutic use of warfarin in clinical practice?

Accepted Answer

Anticoagulation for atrial fibrillation and thromboembolic disease

Answer

Antiplatelet therapy for acute MI

Answer

Treatment of hyperlipidemia

Answer

Management of hypertensive emergencies

Question 5

Which dangerous drug interaction occurs when SSRIs are combined with MAOIs?

Accepted Answer

Serotonin syndrome

Answer

Reduced antidepressant efficacy

Answer

Increased risk of bleeding

Answer

Hypertensive crisis

Question 6

What is the specific antidote for acetaminophen overdose?

Accepted Answer

N-acetylcysteine (NAC)

Answer

Naloxone

Answer

Flumazenil

Answer

Physostigmine