AMC MCQ AMC MCQ - Australian Medical Council Multiple Choice Questions Haematology and Oncology Questions and Answers

Question 1

A 70-year-old presents with fatigue, bone pain, hypercalcaemia, and serum protein electrophoresis showing an M-spike. Bone marrow biopsy shows 30% plasma cells. What is the diagnosis?

Accepted Answer

Multiple myeloma

Answer

Waldenström macroglobulinaemia

Answer

Monoclonal gammopathy of undetermined significance (MGUS)

Answer

Chronic lymphocytic leukaemia

Question 2

A 25-year-old presents with painless cervical lymphadenopathy, fever, night sweats, and weight loss. Biopsy shows Reed-Sternberg cells. What is the most likely diagnosis?

Accepted Answer

Hodgkin lymphoma

Answer

Non-Hodgkin lymphoma

Answer

Infectious mononucleosis

Answer

Sarcoidosis

Question 3

A patient with chronic myeloid leukaemia (CML) is found to have the Philadelphia chromosome t(9;22). Which molecular target does imatinib inhibit?

Accepted Answer

BCR-ABL tyrosine kinase

Answer

BCL-2

Answer

CD20

Answer

VEGFR

Question 4

A 60-year-old patient on warfarin presents with an INR of 8.5 and minor bleeding. What is the most appropriate management?

Accepted Answer

Hold warfarin and administer oral vitamin K 1–2.5 mg

Answer

Continue warfarin and recheck INR in 48 hours

Answer

Administer fresh frozen plasma (FFP)

Answer

Administer prothrombin complex concentrate (PCC)

Question 5

A 45-year-old woman has a microcytic, hypochromic anaemia with serum ferritin of 5 µg/L and low serum iron. What is the most likely cause?

Accepted Answer

Iron deficiency anaemia

Answer

Anaemia of chronic disease

Answer

Thalassaemia trait

Answer

Sideroblastic anaemia

Question 6

Which coagulation factor is deficient in haemophilia A?

Accepted Answer

Factor VIII

Answer

Factor IX

Answer

Factor XI

Answer

von Willebrand factor

A 70-year-old presents with fatigue, bone pain, hypercalcaemia, and serum protein electrophoresis showing an M-spike.Bone marrow biopsy shows 30% plasma cells.What is the diagnosis?

A 70-year-old presents with fatigue, bone pain, hypercalcaemia, and serum protein electrophoresis showing an M-spike.
Bone marrow biopsy shows 30% plasma cells.
What is the diagnosis?