A 62-year-old male with type 2 diabetes and hypertension has the following annual lab results: HbA1c 7.8%, LDL cholesterol 95 mg/dL, eGFR 65 mL/min/1.73m², and a urine albumin-to-creatinine ratio (UACR) of 150 mg/g.
Which of these findings is the most significant early indicator of progressing diabetic kidney disease requiring a potential medication adjustment?