ALAT Species-Specific Care and Experimental Models Questions and Answers Flashcards

Which of the following best describes a transgenic mouse?

Answer: A mouse whose genome has been altered to contain foreign DNA or modified genes

Transgenic mice carry artificially introduced or modified genetic material, enabling researchers to study gene function and model human diseases.

What is the primary purpose of ear notching or ear tagging in laboratory rodents?

Answer: To provide permanent individual identification for research tracking

Ear notching and ear tags provide permanent, individual identification necessary for accurate data tracking in research studies.

Which condition is commonly seen in aged female rats and is characterized by mammary tissue growths?

Answer: Mammary fibroadenoma

Mammary fibroadenomas are common benign tumors in aged female rats, frequently observed as palpable subcutaneous masses.

In a Xenopus laevis (African clawed frog) colony, what is the recommended approach to prevent chytridiomycosis spread?

Answer: Quarantine new animals and practice strict biosecurity to prevent Batrachochytrium dendrobatidis introduction

Strict quarantine and biosecurity measures are the primary strategy to prevent introduction of Batrachochytrium dendrobatidis, which causes the fatal chytridiomycosis in amphibians.

What is 'ringtail' in laboratory rats and what environmental condition causes it?

Answer: Annular constrictions of the tail caused by low humidity

Ringtail is a condition in young rats characterized by annular constrictions and necrosis of the tail, caused by low relative humidity in the housing environment.

Which of the following rodent species is known for its extreme sensitivity to dietary fat and is commonly used in obesity and metabolic syndrome research?

Answer: C57BL/6 mouse

The C57BL/6 mouse strain is highly susceptible to diet-induced obesity and metabolic syndrome on high-fat diets, making it a standard model for these conditions.