AGD Dental Pharmacology 2

Question 1

What is the first-line antibiotic for treating odontogenic infections in patients without penicillin allergy?

Accepted Answer

Amoxicillin

Answer

Metronidazole

Answer

Clindamycin

Answer

Azithromycin

Question 2

Metronidazole is particularly effective in treating periodontal and odontogenic infections because it is active against:

Accepted Answer

Strict anaerobic microorganisms

Answer

Gram-positive aerobic cocci

Answer

Gram-negative aerobic rods

Answer

Mycobacterial organisms

Question 3

Which antibiotic causes permanent intrinsic staining of developing teeth when administered to children under age 8?

Accepted Answer

Tetracycline

Answer

Amoxicillin

Answer

Clindamycin

Answer

Metronidazole

Question 4

Clavulanic acid is added to amoxicillin (Augmentin) primarily because it:

Accepted Answer

Inhibits bacterial beta-lactamase enzymes

Answer

Enhances amoxicillin penetration into bone

Answer

Extends the plasma half-life of amoxicillin

Answer

Reduces gastrointestinal adverse effects

Question 5

Clindamycin exerts its antibacterial effect by:

Accepted Answer

Binding to the 50S ribosomal subunit and inhibiting protein synthesis

Answer

Inhibiting bacterial cell wall synthesis

Answer

Disrupting the bacterial cell membrane

Answer

Inhibiting DNA gyrase (topoisomerase II)

Question 6

The combination of amoxicillin plus metronidazole is used in aggressive periodontal therapy because:

Accepted Answer

Together they cover both Aggregatibacter actinomycetemcomitans and strict anaerobes

Answer

They are both bacteriostatic and act synergistically

Answer

Both drugs are dosed once daily for convenience

Answer

Combined, they reduce the risk of antibiotic resistance

Question 7

A penicillin-allergic patient requires antibiotic prophylaxis before a dental procedure. According to AHA guidelines, an appropriate alternative is:

Accepted Answer

Azithromycin 500 mg orally

Answer

Ampicillin 2 g orally

Answer

Ciprofloxacin 500 mg orally

Answer

Metronidazole 500 mg orally