PTCB Drug Test #6 3 — Questions and Answers
Question 1: How many milliliters of a 20 mg/mL morphine injection are needed to provide a 15 mg dose?
- 1.5 mL
- 0.75 mL (Correct answer)
- 3 mL
- 2 mL
Correct answer: 0.75 mL
Volume = dose ÷ concentration = 15 mg ÷ 20 mg/mL = 0.75 mL.
Question 2: What is the generic name for Xarelto?
- Dabigatran
- Edoxaban
- Apixaban
- Rivaroxaban (Correct answer)
Correct answer: Rivaroxaban
Xarelto is the brand name for rivaroxaban, a direct Factor Xa inhibitor anticoagulant used for VTE prevention/treatment, pulmonary embolism, and stroke prevention in A-fib.
Question 3: Which of the following drug interactions is most clinically significant for simvastatin?
- Taking with food
- Concurrent use with strong CYP3A4 inhibitors (e.g., clarithromycin) (Correct answer)
- Concurrent use with antacids
- Taking at different times of day
Correct answer: Concurrent use with strong CYP3A4 inhibitors (e.g., clarithromycin)
Simvastatin is metabolized by CYP3A4. Strong inhibitors like clarithromycin, ketoconazole, or HIV protease inhibitors dramatically increase simvastatin levels, raising the risk of myopathy and rhabdomyolysis.
Question 4: Which government form is used to order Schedule II controlled substances from a DEA-registered distributor?
- DEA Form 41
- DEA Form 222 (or CSOS) (Correct answer)
- DEA Form 106
- DEA Form 224
Correct answer: DEA Form 222 (or CSOS)
DEA Form 222 (or its electronic equivalent CSOS - Controlled Substance Ordering System) is required to order Schedule I and II controlled substances from a registered distributor.
Question 5: Metoprolol tartrate 25 mg BID is equivalent to how many mg per day?
- 25 mg/day
- 100 mg/day
- 75 mg/day
- 50 mg/day (Correct answer)
Correct answer: 50 mg/day
BID = twice daily. 25 mg x 2 doses = 50 mg/day. Metoprolol tartrate is the immediate-release form (Lopressor) dosed multiple times daily, vs. metoprolol succinate (Toprol XL) which is once daily.
Question 6: Which of the following is TRUE about handling hazardous drugs in the pharmacy?
- No special precautions are needed for oral hazardous drugs
- Hazardous drugs may be compounded on any clean surface
- NIOSH guidelines require use of appropriate PPE including double gloves (Correct answer)
- All hazardous drugs must be mixed in a horizontal laminar airflow hood
Correct answer: NIOSH guidelines require use of appropriate PPE including double gloves
NIOSH guidelines (and USP 800) require appropriate PPE for all hazardous drug handling, including double chemotherapy-tested gloves, gowns, and proper respiratory protection. Hazardous drugs must be prepared in negative-pressure isolators, not horizontal hoods.
PTCB Drug Test #6 3
How many milliliters of a 20 mg/mL morphine injection are needed to provide a 15 mg dose?