NAVLE Feline Infectious 2 — Questions and Answers
Question 1: A cat presents with corneal sequestrum and chronic ocular discharge. Which herpesvirus is most commonly implicated in this condition?
- Feline calicivirus
- Feline herpesvirus-1 (Correct answer)
- Feline leukemia virus
- Feline immunodeficiency virus
Correct answer: Feline herpesvirus-1
Feline herpesvirus-1 (FHV-1) is strongly associated with corneal sequestrum formation due to chronic corneal inflammation and ulceration.
Question 2: Which feline coronavirus (FCoV) mutation is classically associated with the transition from enteric infection to feline infectious peritonitis (FIP)?
- Spike protein S1 domain deletion
- Nucleocapsid gene frameshift
- 3c gene loss-of-function mutation (Correct answer)
- 7b gene duplication
Correct answer: 3c gene loss-of-function mutation
Loss-of-function mutations in the 3c gene of feline enteric coronavirus are associated with the shift to macrophage tropism and development of FIP.
Question 3: A 3-year-old intact male cat tests FIV-positive. What is the most reliable route of transmission for this virus?
- Shared food bowls
- Bite wounds (Correct answer)
- Fomite contact
- Vertical transmission via placenta
Correct answer: Bite wounds
FIV is most efficiently transmitted through bite wounds because high viral loads are present in saliva.
Question 4: Feline panleukopenia virus (FPV) primarily targets which tissue due to its requirement for rapidly dividing cells?
- Hepatocytes
- Renal tubular epithelium
- Intestinal crypt epithelium (Correct answer)
- Pulmonary alveolar cells
Correct answer: Intestinal crypt epithelium
FPV targets rapidly dividing intestinal crypt cells, leading to villous collapse, malabsorption, and severe hemorrhagic enteritis.
Question 5: A cat with confirmed FeLV infection is most likely to develop which neoplastic condition?
- Mammary adenocarcinoma
- Hepatocellular carcinoma
- Multicentric lymphoma (Correct answer)
- Mast cell tumor
Correct answer: Multicentric lymphoma
FeLV strongly predisposes cats to multicentric lymphoma, particularly T-cell lymphoma in young cats.
Question 6: Which antifungal is the treatment of choice for feline cryptococcosis affecting the CNS?
- Ketoconazole
- Fluconazole (Correct answer)
- Amphotericin B alone
- Terbinafine
Correct answer: Fluconazole
Fluconazole achieves excellent CNS penetration and is the preferred long-term treatment for feline cryptococcal meningoencephalitis.
Question 7: A cat from a shelter presents with vesicular oral lesions and limping. Which pathogen is most likely responsible?
- Feline herpesvirus-1
- Feline calicivirus (Correct answer)
- Feline leukemia virus
- Bordetella bronchiseptica
Correct answer: Feline calicivirus
Feline calicivirus causes oral ulcerations and acute lameness syndrome (virulent systemic FCV strains), distinguishing it from FHV-1 which rarely causes limb disease.
NAVLE Feline Infectious 2
A cat presents with corneal sequestrum and chronic ocular discharge.
Which herpesvirus is most commonly implicated in this condition?