MFDS Oral Medicine & Pathology 1 — Questions and Answers
Question 1: The most common type of odontogenic cyst is the:
- Dentigerous cyst
- Lateral periodontal cyst
- Odontogenic keratocyst
- Radicular cyst (Correct answer)
Correct answer: Radicular cyst
Radicular cysts (periapical cysts) are the most common odontogenic cysts, arising from proliferation of the epithelial cell rests of Malassez in response to periapical inflammation.
Question 2: Wickham's striae are a characteristic feature of which condition?
- Pemphigus vulgaris
- Oral lichen planus (Correct answer)
- Erythema multiforme
- Recurrent aphthous stomatitis
Correct answer: Oral lichen planus
Wickham's striae are fine white interlacing lines seen in reticular oral lichen planus and are considered pathognomonic of this condition.
Question 3: Which virus is most strongly associated with the development of oral hairy leukoplakia?
- HSV-1
- HPV-16
- EBV (Correct answer)
- CMV
Correct answer: EBV
Oral hairy leukoplakia is caused by Epstein-Barr virus (EBV) replication in epithelial cells, typically occurring in immunocompromised individuals.
Question 4: Nikolsky's sign is positive in which oral condition?
- Oral lichen planus
- Pemphigus vulgaris (Correct answer)
- Denture stomatitis
- Geographic tongue
Correct answer: Pemphigus vulgaris
Nikolsky's sign (extension of a blister with lateral pressure on normal-appearing mucosa) is positive in pemphigus vulgaris due to loss of desmosomal adhesion.
Question 5: The most common site for oral squamous cell carcinoma in the UK is the:
- Hard palate
- Floor of mouth and lateral tongue (Correct answer)
- Buccal mucosa
- Gingiva
Correct answer: Floor of mouth and lateral tongue
The floor of mouth and lateral/ventral tongue represent the highest-risk sites for oral squamous cell carcinoma in the UK population.
Question 6: Ameloblastoma most commonly arises in which jaw location?
- Anterior maxilla
- Posterior mandible (Correct answer)
- Anterior mandible
- Posterior maxilla
Correct answer: Posterior mandible
Approximately 80% of ameloblastomas occur in the mandible, with the majority found in the posterior body and ramus region.
MFDS Oral Medicine & Pathology 1
The most common type of odontogenic cyst is the: