CLT CLT Wound Healing & Tissue Repair 1 — Questions and Answers
Question 1: Which phase of wound healing involves the formation of a fibrin clot and platelet aggregation?
- Proliferative phase
- Remodeling phase
- Hemostasis phase (Correct answer)
- Inflammatory phase
Correct answer: Hemostasis phase
Hemostasis is the first wound healing phase, characterized by platelet aggregation and fibrin clot formation to stop bleeding immediately after tissue injury.
Question 2: How does laser therapy (photobiomodulation) accelerate the inflammatory phase of wound healing?
- By suppressing all immune cell activity
- By modulating cytokine release and enhancing macrophage activity to resolve inflammation faster (Correct answer)
- By cauterizing the wound edges
- By increasing scar tissue formation
Correct answer: By modulating cytokine release and enhancing macrophage activity to resolve inflammation faster
Photobiomodulation modulates pro- and anti-inflammatory cytokines and stimulates macrophage phagocytosis, helping the inflammatory phase resolve more efficiently.
Question 3: During the proliferative phase of wound healing, which cell type is primarily responsible for depositing new collagen?
- Macrophages
- Fibroblasts (Correct answer)
- Neutrophils
- Platelets
Correct answer: Fibroblasts
Fibroblasts are the principal cells in the proliferative phase, synthesizing and depositing collagen to form the new extracellular matrix that fills the wound.
Question 4: What is the role of angiogenesis in wound healing, and how does laser therapy support it?
- Angiogenesis destroys old vessels; laser prevents it
- Angiogenesis forms new blood vessels to supply oxygen; laser stimulates VEGF to promote this process (Correct answer)
- Angiogenesis is irrelevant to wound healing
- Angiogenesis only occurs in bone healing
Correct answer: Angiogenesis forms new blood vessels to supply oxygen; laser stimulates VEGF to promote this process
Angiogenesis forms new capillaries to supply oxygen and nutrients to healing tissue; photobiomodulation upregulates VEGF (vascular endothelial growth factor) to enhance this process.
Question 5: Which type of chronic wound is most commonly treated with laser therapy in US clinical practice?
- Paper cuts
- Diabetic foot ulcers, pressure injuries, and venous stasis ulcers (Correct answer)
- Surgical incisions less than 24 hours old
- Burn wounds requiring skin grafts
Correct answer: Diabetic foot ulcers, pressure injuries, and venous stasis ulcers
Diabetic foot ulcers, pressure injuries, and venous stasis ulcers are the most common chronic wounds treated with laser therapy due to their impaired healing mechanisms.
Question 6: What is 'granulation tissue' and why is its formation a positive sign during laser-assisted wound healing?
- Granulation tissue is scar tissue indicating healing failure
- It is new vascular connective tissue filling the wound bed, indicating active proliferative healing (Correct answer)
- It is a bacterial biofilm on the wound surface
- Granulation tissue indicates infection
Correct answer: It is new vascular connective tissue filling the wound bed, indicating active proliferative healing
Granulation tissue is newly formed vascular connective tissue consisting of fibroblasts, collagen, and new capillaries, indicating that the wound is actively progressing through the proliferative healing phase.
CLT CLT Wound Healing & Tissue Repair 1
Which phase of wound healing involves the formation of a fibrin clot and platelet aggregation?