ABD Reading 2 — Questions and Answers
Question 1: A 45-year-old presents with a well-demarcated, salmon-colored plaque with silvery scale on the extensor elbow. Pinpoint bleeding appears when scale is removed. What is this sign called?
- Auspitz sign (Correct answer)
- Nikolsky sign
- Darier sign
- Koebner sign
Correct answer: Auspitz sign
The Auspitz sign is pinpoint bleeding after removal of psoriatic scale, reflecting dilated dermal capillaries.
Question 2: Which histologic feature is most characteristic of psoriasis vulgaris?
- Munro microabscesses (Correct answer)
- Civatte bodies
- Grenz zone
- Pautrier microabscesses
Correct answer: Munro microabscesses
Munro microabscesses are collections of neutrophils in the stratum corneum, a hallmark of psoriasis.
Question 3: A drug used for severe psoriasis inhibits dihydrofolate reductase and requires folic acid supplementation. What is it?
- Methotrexate (Correct answer)
- Cyclosporine
- Acitretin
- Apremilast
Correct answer: Methotrexate
Methotrexate inhibits dihydrofolate reductase and warrants folic acid to reduce toxicity.
Question 4: Which biologic class targets IL-17A and is used for moderate-to-severe plaque psoriasis?
- Secukinumab (Correct answer)
- Adalimumab
- Ustekinumab
- Rituximab
Correct answer: Secukinumab
Secukinumab is a monoclonal antibody against IL-17A effective in plaque psoriasis.
Question 5: A patient with psoriasis develops new plaques along a linear scratch mark. This phenomenon is termed:
- Koebner phenomenon (Correct answer)
- Auspitz sign
- Wickham striae
- Pathergy
Correct answer: Koebner phenomenon
The Koebner phenomenon is the appearance of lesions at sites of skin trauma.
Question 6: Which nail finding is most commonly associated with psoriasis?
- Pitting (Correct answer)
- Koilonychia
- Beau lines
- Mees lines
Correct answer: Pitting
Nail pitting results from parakeratotic foci in the proximal nail matrix in psoriasis.
Question 7: Guttate psoriasis in a child is classically preceded by which infection?
- Streptococcal pharyngitis (Correct answer)
- Herpes simplex
- Varicella
- Molluscum contagiosum
Correct answer: Streptococcal pharyngitis
Guttate psoriasis frequently follows a streptococcal throat infection.
ABD Reading 2
A 45-year-old presents with a well-demarcated, salmon-colored plaque with silvery scale on the extensor elbow.
Pinpoint bleeding appears when scale is removed.
What is this sign called?